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HelpTEST ID TGMS Thyroglobulin Mass Spectrometry, Serum
Reporting Name
Thyroglobulin, Mass Spec., SSpecimen Type
Serum RedSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: None (gel tubes/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1.25 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.75 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 7 days |
| Frozen | 416 days | |
| Ambient | 72 hours |
Method Name
Tryptic Protein Fragmentation, purified with Immunocapture, Analysis by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
(This service is performed pursuant to an agreement with SISCAPA Assay Technologies Inc. covering US Patent 7,632,686)
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Healthy individuals with intact, functioning thyroid: ≤33 ng/mL
Day(s) Performed
Monday through Friday
Report Available
3 to 10 daysSpecimen Retention Time
14 monthsPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
84432
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Oncology Test Request (T729)
-Renal Diagnostics Test Request (T830)
Useful For
Accurate measurement of serum thyroglobulin (Tg) in patients with known or suspected antithyroglobulin autoantibodies (TgAb) or heterophile antibodies (HAb)
Reflex testing of samples with previously unknown TgAb status that prove TgAb positive during immunoassay testing
Assisting in the differential diagnosis of early phase silent thyroiditis versus Graves disease in patients without thyroid cancer (the mass spectrometry-based method would only be required if these patients have TgAb or HAb)