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HelpTEST ID SHBG1 Sex Hormone-Binding Globulin, Serum
Reporting Name
Sex Hormone-Binding Globulin, SSpecimen Type
SerumSpecimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days | ||
| Ambient | 7 days |
Method Name
Immunoenzymatic Assay
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
CHILDREN:
Males
|
Tanner Stages |
Mean Age |
Reference Interval (nmol/L) |
|
Stage I |
10.4 |
17-135 |
|
Stage II |
11.1 |
21-114 |
|
Stage III |
12.7 |
12-138 |
|
Stage IV |
14.5 |
7.7-67 |
|
Stage V |
14.2 |
3.9-40 |
Females
|
Tanner Stages |
Mean Age |
Reference Interval (nmol/L) |
|
Stage I |
10.5 |
16-182 |
|
Stage II |
10.9 |
24-121 |
|
Stage III |
12.5 |
18-87 |
|
Stage IV |
14 |
7.7-108 |
|
Stage V |
14.9 |
10-79 |
ADULTS:
Males
≥18 years: 13.3-89.5 nmol/L
Females
18-46 years: 18.2-135.5 nmol/L
47-91 years: post-menopausal: 16.8-125.2 nmol/L
Day(s) Performed
Monday through Saturday
Report Available
1 to 3 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
84270
Useful For
Diagnosis and follow-up of women with signs or symptoms of androgen excess (eg, polycystic ovarian syndrome and idiopathic hirsutism)
An adjunct in monitoring sex-steroid and antiandrogen therapy
An adjunct in the diagnosis of disorders of puberty
An adjunct in the diagnosis and follow-up of anorexia nervosa
An adjunct in the diagnosis of thyrotoxicosis (tissue marker of thyroid hormone excess)
A possible adjunct in diagnosis and follow-up of insulin resistance and cardiovascular and type 2 diabetes risk assessment, particularly in women
Highlights
Sex hormone-binding globulin (SHBG) is a major carrier protein for sex steroids in the blood.
Determination of SHBG concentrations is useful in the investigation of cases of suspected androgen excess, such as polycystic ovarian syndrome or idiopathic hirsutism.
SHBG concentration measurements may be useful in the evaluation of infertility, disorders of puberty, thyrotoxicosis, and in the monitoring of sex-steroid and anti-androgen therapies.