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HelpTEST ID RLTE4 Leukotriene E4, Random, Urine
Reporting Name
Leukotriene E4, Random, USpecimen Type
UrineOrdering Guidance
Patients with mast cell activation syndrome may have chronically elevated leukotriene E4 (LTE4), however, in certain situations LTE4 can exhibit intermittent elevations. In these cases, a 24-hour urine collection is preferred. For 24-hour urine collection, order TLTE4 / Leukotriene E4, 24 Hour, Urine.
Additional Testing Requirements
For an optimal evaluation, testing for urinary leukotriene E4 should be accompanied with laboratory investigations for the presence of serum tryptase (TRYPT / Tryptase, Serum), urinary 2,3-dinor 11 beta-prostaglandin F2 alpha (23BPR / 2,3-Dinor 11 Beta-Prostaglandin F2 Alpha, Random, Urine) and urinary N-methylhistamine (NMHR / N-Methylhistamine, Random, Urine).
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Container/Tube: Plastic vial
Specimen Volume: 5 mL
Collection Instructions:
1. Within a few hours of symptom onset, collect a random urine specimen.
2. No preservative
3. Aliquot urine into a plastic vial and send frozen.
Specimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen (preferred) | 28 days | |
| Refrigerated | 7 days | ||
| Ambient | 24 hours |
Method Name
LTE4R: Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
CRTFR: Enzymatic Colorimetric Assay
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
LEUKOTRIENE E4
≤104 pg/mg creatinine
CREATININE
≥18 years old: 16-326 mg/dL
Reference values have not been established for patients who are younger than 18 years of age.
Day(s) Performed
Monday, Tuesday, Thursday
Report Available
2 to 9 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82542
82570
Useful For
Aiding in the evaluation of patients at-risk for mast cell activation syndrome (eg, systemic mastocytosis, IgE-mediated allergies, or aspirin-exacerbated respiratory disease) using random urine collections
Highlights
Quantitation of urinary metabolites of histamine, prostaglandin D2, and leukotriene E4 may provide significant clues for the diagnosis and management of symptomatic patients with both clonal and nonclonal mast cell activation syndromes. The presence of 1 or more elevated levels of these biomarkers in urine greatly narrows diagnostic possibilities for causes of symptoms; informs the practitioner what specific metabolic pathways are involved; and targets the treatment in a specific, personalized fashion.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| LTE4R | Leukotriene E4, Random, U | No | Yes |
| CRTFR | Creatinine, Random, U | No | Yes |