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HelpTEST ID PR3 Proteinase 3 Antibodies, IgG, Serum
Reporting Name
Proteinase 3 Ab (PR3), SSpecimen Type
SerumAdditional Testing Requirements
To distinguish between granulomatosis with polyangiitis and other forms of anti-neutrophil cytoplasmic antibody-associated vasculitis, also order MPO / Myeloperoxidase Antibodies, IgG, Serum and ANCA / Cytoplasmic Neutrophil Antibodies, Serum; alternatively, VASC / Antineutrophil Cytoplasmic Antibodies Vasculitis Panel, Serum may be ordered instead, which initially tests for MPO and proteinase 3 antibodies, with reflex to ANCA when appropriate.
Specimen Required
Supplies: Sarstedt Aliquot Tube 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.35 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 21 days | |
| Frozen | 21 days |
Special Instructions
Method Name
Multiplex Flow Immunoassay
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reference Values
<0.4 U (negative)
0.4-0.9 U (equivocal)
≥1.0 U (positive)
Reference values apply to all ages.
Day(s) Performed
Monday through Saturday
Report Available
2 to 3 daysSpecimen Retention Time
14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83516
Forms
If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.
Useful For
Evaluating patients with clinical features of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, specifically granulomatosis with polyangiitis (GPA), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis
Distinguishing between GPA and other forms of ANCA-associated vasculitis, in conjunction with myeloperoxidase antibody and cytoplasmic neutrophil antibody testing
Following treatment response or monitoring disease activity in patients with proteinase 3 antibodies