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TEST ID PQNRU Porphyrins, Quantitative, Random, Urine

Important Note

This random urine test should be ordered when the specimen will reach Mayo Clinic Laboratories within 72 hours.

Please note: Specimen collected on Friday or Saturday could potentially arrive to Mayo outside of stability.  Holiday weekends and Holiday Mondays will also increase transport times. 

Reporting Name

Porphyrins, QN, Random, U

Specimen Type

Urine


Ordering Guidance


This random urine test should be ordered when the specimen will reach Mayo Clinic Laboratories within 72 hours. If transportation will take longer than 72 hours, order PQNU / Porphyrins, Quantitative, 24 Hour, Urine and follow collection guidelines.



Shipping Instructions


Ship specimen in amber bottle to protect from light.



Necessary Information


Include a list of medications the patient is currently taking.



Specimen Required


Patient Preparation: Patient should not consume any alcohol for the 24 hours before specimen collection.

Supplies: Urine Container - Amber, 60 mL (T596)

Container/Tube: Amber, 60-mL urine container

Specimen Volume: 20 to 50 mL

Collection Instructions: Collect a random urine specimen.


Specimen Minimum Volume

15 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen 72 hours LIGHT PROTECTED

Testing Algorithm

The following algorithms are available:

-Porphyria (Acute) Testing Algorithm

 

-Porphyria (Cutaneous) Testing Algorithm 

 

Method Name

High-Performance Liquid Chromatography (HPLC) with Fluorometric Detection/Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

Uroporphyrins, Octacarboxyl:

≤30 nmol/L

 

Heptacarboxylporphyrins:

≤7 nmol/L

 

Hexacarboxylporphyrins:

≤2 nmol/L

 

Pentacarboxyporphyrins:

≤5 nmol/L

 

Copropprphyrin, Tetracboxyl:

≤110 nmol/L

 

Porphobilinogen:

≤1.3 mcmol/L

Day(s) Performed

Monday through Friday

Report Available

2 to 4 days

Specimen Retention Time

1 week

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

84110-Porphobilinogen, quantitative

84120-Porphyrins, quantitation and fractionation

Useful For

Preferred test to begin assessment for congenital erythropoietic porphyria and porphyria cutanea tarda and during symptomatic periods for acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria when specimen transport will not exceed 72 hours

Genetics Test Information

This test is preferred test during symptomatic periods for acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria. The random urine collection for this test allows for the diagnosis to be established and treatment to be initiated quickly. However, this test should only be ordered when the specimen will be received at Mayo Clinic Laboratories within 72 hours of collection. If it will be longer, PQNU / Porphyrins, Quantitative, 24 Hour, Urine should be ordered and collection guidelines must be followed.

 

Testing includes porphobilinogen which is useful in the evaluation of the acute porphyrias.

 

This is the preferred test to begin assessment for congenital erythropoietic porphyria and porphyria cutanea tarda.