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TEST ID GB2GP Beta-2 Glycoprotein 1 Antibodies, IgG, Serum

Reporting Name

Beta 2 GP1 Ab IgG, S

Specimen Type

Serum


Additional Testing Requirements


Diagnostic criteria for antiphospholipid syndrome include the presence of at least one of the following: lupus anticoagulant, anticardiolipin, and anti-beta-2 glycoprotein 1 IgG or IgM antibodies. Consider ordering CLPMG / Phospholipid (Cardiolipin) Antibodies, IgG and IgM, Serum; MB2GP / Beta-2 Glycoprotein 1 Antibodies, IgM, Serum; and ALUPP / Lupus Anticoagulant Profile, Plasma concurrently with this test.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK
Heat-treated specimens Reject

Reference Values

<15.0 SGU (negative)

15.0-39.9 SGU (weakly positive)

40.0-79.9 SGU (positive)

≥80.0 SGU (strongly positive)

Results are reported in standard IgG anti-beta 2 glycoprotein 1 units (SGU).

 

Reference values apply to all ages.

Day(s) Performed

Monday through Saturday

Report Available

2 to 6 days

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86146

Useful For

Evaluating patients with suspected antiphospholipid syndrome by identification of beta-2 glycoprotein 1 IgG antibodies

 

First-line test when antiphospholipid syndrome is strongly suspected, in conjunction with cardiolipin antibodies (IgG and IgM) and lupus anticoagulant testing

 

Estimating the risk of thrombosis and/or pregnancy-related morbidity in patients with systemic lupus erythematosus