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TEST ID CRS Chromium, Serum

Reporting Name

Chromium, S

Specimen Type

Serum


Ordering Guidance


The US Food and Drug Administration recommended test for monitoring chromium in patients with metal-on-metal implants is CRWB / Chromium, Blood.



Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies:

-Metal Free B-D Tube (No Additive), 6 mL (T184)

-Metal Free Specimen Vial (T173)

Collection Container/Tube: 6 mL Plain, royal blue-top Vacutainer plastic trace element blood collection tube

Submission Container/Tube: 7-mL Mayo metal-free, screw-capped, polypropylene vial

Specimen Volume: 1.6 mL Serum

Collection Instructions: See Metals Analysis Specimen Collection and Transport for complete instructions.


Specimen Minimum Volume

Serum: 0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days METAL FREE
  Ambient  28 days METAL FREE
  Frozen  28 days METAL FREE

Method Name

Triple-Quadrupole Inductively Coupled Plasma-Mass Spectrometry (ICP-MS/MS)

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

<0.4 ng/mL

 

When collected by a phlebotomist experienced in ultra-clean collection technique and handled according to the instructions in Metals Analysis Specimen Collection and Transport, we have observed the concentration of chromium in serum to be below 0.4 ng/mL. However, the majority of specimens submitted for analysis from unexposed individuals contain 0.1 ng/mL to 0.3 ng/mL of chromium. Commercial evacuated blood collection tubes not designed for trace-metal specimen collection yield serum containing 2.0 ng/mL to 5.0 ng/mL chromium derived from the collection tube.

Day(s) Performed

Monday through Friday

Report Available

1 to 4 days

Specimen Retention Time

14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82495

Useful For

Screening for occupational exposure

 

Monitoring metallic prosthetic implant wear