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HelpTEST ID CPAVP Copeptin proAVP, Plasma
Reporting Name
Copeptin proAVP, PSpecimen Type
Plasma EDTASpecimen Required
Patient Preparation: For water-deprivation testing, for at least 8 hours, the patient should fast and thirst (no liquids, including water, are allowed).
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic screw-top vial
Specimen Volume: 0.5 mL
Collection Information: Centrifuge and aliquot plasma into a plastic vial. Do not submit in original tube.
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Refrigerated (preferred) | 7 days | |
| Frozen | 30 days | ||
| Ambient | 7 days |
Method Name
Immunofluorescent Assay (IFA)
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Non-water deprived, non-fasting adults*: <13.1 pmol/L
Water deprived, fasting adults**: <15.2 pmol/L
Non-water deprived, non-fasting pediatric patients***: <14.5 pmol/L
Note:
*Keller T, Tzikas S, Zeller T, et al. Copeptin improves early diagnosis of acute myocardial infarction. J Am Coll Cardiol. 2010;55(19):2096-2106. doi:10.1016/j.jacc.2010.01.029
**Internal Mayo Clinic study
***Du JM, Sang G, Jiang CM, He XJ, Han Y. Relationship between plasma copeptin levels and complications of community-acquired pneumonia in preschool children. Peptides. 2013;45:61-65. doi:10.1016/j.peptides.2013.04.015
Day(s) Performed
Monday through Saturday
Report Available
Same day/1 to 3 daysSpecimen Retention Time
2 weeksPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
84588
Useful For
Investigating the differential diagnosis for patients with water balance disorders, including diabetes insipidus, in conjunction with osmolality and hydration status
May aid in the evaluation of cardiovascular disease in conjunction with other cardiac markers