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HelpTEST ID ALS Aldolase, Serum
Reporting Name
Aldolase, SSpecimen Type
Serum RedSpecimen Required
Supplies: Sarstedt 5 mL Aliquot Tube (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Within 1 hour of collection, centrifuge and aliquot serum into a plastic vial.
2. Send refrigerated.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 7 days |
| Frozen | 60 days |
Method Name
Photometric
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
<18 years: <14.5 U/L
≥18 years: <7.7 U/L
Day(s) Performed
Monday through Sunday
Report Available
1 to 3 daysSpecimen Retention Time
7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82085
Forms
If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.
Useful For
Detection of muscle disease
Clinical Information
Aldolase is necessary for glycolysis in muscle as a rapid response pathway for production of adenosine triphosphate independent of tissue oxygen.
Aldolase catalyzes the conversion of fructose 1,6-diphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, an important reaction in the glycolytic breakdown of glucose to lactate in muscle.
Aldolase is a tetramer whose primary structure depends upon the tissue from which it was synthesized (highest expression in liver, muscle, brain).
Elevated values are found in muscle diseases, such as Duchenne muscular dystrophy, dermatomyositis, polymyositis, and limb-girdle muscular dystrophy. While elevated creatinine kinase (CK) levels are more sensitive and specific for muscle disease, occasionally elevated aldolase is observed in some patients with myositis that have normal CK values.