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HelpTEST ID 21OH 21-Hydroxylase Antibodies, Serum
Reporting Name
21-Hydroxylase Ab, SSpecimen Type
SerumOrdering Guidance
Testing for autoantibodies against 21-hydroxylase is recommended following confirmation of adrenal insufficiency to help differentiate between causes of primary adrenal insufficiency
Shipping Instructions
Ship specimen frozen on dry ice
Specimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial to remove from cells or gel prior to shipping.
Specimen Minimum Volume
0.2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Frozen | 14 days |
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
Negative
Day(s) Performed
Wednesday
Report Available
3 to 9 daysSpecimen Retention Time
2 weeksPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83516
Useful For
Investigating adrenal insufficiency
Aiding in the detection of those at risk of developing autoimmune adrenal failure in the future
Highlights
Addison disease is the most frequent cause of primary adrenal insufficiency.
Autoantibodies against 21-hydroxylase are present in up to 90% of Addison disease cases.
Measurement of anti-21-hydroxylase autoantibodies is useful in the evaluation of the cause of established primary adrenal insufficiency.